The laboratory of Ethan M. Goldberg (goldbergneurolab.com) at The Children’s Hospital of Philadelphia and The University of Pennsylvania, in Philadelphia, PA, U.S.A., is recruiting a postdoctoral fellow interested in studying mechanisms of epilepsy in novel experimental models. Our research interests and approaches include:
Study of epilepsy-associated ion channel variants expressed in heterologous systems, in neurons in culture, in acute brain slices, and in neurons derived from human induced pluripotent stem cells (iPSCs);
Treatment of epilepsy and modulation of cerebral cortical circuits in experimental models using GABAergic interneurons derived from mouse ES cells and human iPSCs;
Investigation of epilepsy mechanisms in acute brain slices in vitro and in awake, behaving experimental animals using cellular neurophysiology, EEG, optogenetics, and two-photon calcium imaging.
The laboratory recently identified mutations in the gene SCN3A encoding the voltage-gated sodium channel Nav1.3 as a novel cause of very early onset epileptic encephalopathy (Zaman et al., 2018. Annals of Neurology. 83(4):703-717) and we are continuing to study this further using novel approaches. The laboratory has also made novel insights into pathomechanisms of Dravet syndrome (http://www.jneurosci.org/content/early/2018/08/13/JNEUROSCI.0193-18.2018).
There will be opportunities to develop new and exciting avenues of research at the intersection of cellular neurophysiology, inhibition, neural circuits, and disease, using a range of cutting-edge neuroscience techniques.
About the Employer: Dr. Goldberg is Assistant Professor in the Departments of Neurology & Neuroscience at The University of Pennsylvania and The Children’s Hospital of Philadelphia. The Children's Hospital of Philadelphia is an elite children’s hospital located on the CHOP/UPenn campus and has a long and distinguished tradition of research that has spanned nearly a century. The larger University of Pennsylvania neuroscience community is a rich academic environment comprised of over 200 faculty with almost 100 neuroscience-related interest groups.
The successful applicant should be a recent graduate with a Ph.D. in neuroscience or related/applied field (physiology, electrical or biomedical engineering, computer science). Prior experience with animal behavior, electrophysiology, imaging, and/or computational neuroscience, is required.
Interested individuals should send a brief cover letter, CV, and references and/or letters of recommendation to Dr. Goldberg at: firstname.lastname@example.org. The position will initially be for one year, with yearly extensions based upon satisfactory yearly review.
Additional Salary Information: Salary is commensurate with experience and qualifications.
Internal Number: 2
About The Children's Hospital of Philadelphia
The Children's Hospital of Philadelphia has a long and distinguished tradition of research that has spanned nearly a century. The research breakthroughs at Children's Hospital have improved the lives of countless children throughout the world and put the institution on the course to pediatric research preeminence. Today, the Hospital's entire research enterprise is organized under the aegis of the CHOP Research Institute and constitutes a separate organizational, administrative and financial entity within the Hospital. CHOP is part of the larger University of Pennsylvania system which has a rich neuroscience community and shares a campus with the School of Engineering, School of Medicine, and the College of the University of Pennsylvania. While Research Institute investigators have academic homes in one of the Hospital's six departments and hold faculty appointments at the University of Pennsylvania, researchers also belong to designated Centers of Emphasis and interdisciplinary, cross-divisional Research Affinity Groups. These groups, as well as investigators and their research programs, are supported by more than a dozen Core Facilities that substantially enhance basic and clinic...al research programs. The cores provide investigators with sophisticated research equipment, knowledgeable advisors and experienced support staff. The Research Institute invests annually in refreshing the cores and acquiring new cutting-edge resources to ensure that investigators have access to the best tools available.
Today, The Children's Hospital of Philadelphia Research Institute is home to one of the largest pediatric research programs in the country with more than $138 million in total federal awards and an annual budget of more than $329 million (FY14).