A postdoctoral position is available in the Stuart Lipton lab at The Scripps Research Institute (TSRI), La Jolla, CA, to study neurodevelopmental and neurodegenerative diseases using patient-derived human induced pluripotent stem cells (hiPSCs) as well as genetic mouse models. Our goal is to understand how specific gene mutations and posttranslational modifications that mimic the effect of such mutations, such as aberrant protein S-nitrosylation, contribute to synaptic damage. We also develop new drug therapies for these diseases. Ongoing research in the lab uses “disease-in-a-dish” models generated from hiPSCs in 2D cultures and 3D-brain organoids (“mini-brains”). A plethora of techniques are employed including chemical biology, molecular biology, patch-clamp electrophysiology and calcium imaging.The candidate is expected to be highly motivated, possess an ability to troubleshoot and work well independently and with others. Tissue culture, neuroscience and molecular biology experience is preferred.
We are looking for individuals who want to study both transgenic/knock out mouse and hiPSC-based models, and who meet the following criteria:
1) Ph.D. in neuroscience, biology, pharmacology, or a related field. 2) A track record of thoughtful scientific inquiry (e.g., first author publication). 3) Experience at the intersection of two or more of the following fields: Cell biology, molecular biology, biochemistry, confocal imaging/quantitative neurohistology, electrophysiology, pharmacology, data analysis.
Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Internal Number: 11119
About The Scripps Research Institute (TSRI)
The Scripps Research Institute (TSRI) is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. The institute has 250 laboratories employing 2,400 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds nearly 1,000 patents, produced 8 FDA-approved therapeutics, and has generated over 70 spin-off companies. According to the 2017 Nature Innovation Index, TSRI is the #1 most influential research institution in the world.